1pad Summary

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PDB entry 1pad (supersedes 2pap)

Binding of chloromethyl ketone substrate analogues to crystalline papain

The structure was published by Drenth, J., Kalk, K.H., and Swen, H.M., in 1976 in a paper entitled "Binding of chloromethyl ketone substrate analogues to crystalline papain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1976.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PAPAIN and ACETYL-ALA-ALA-PHE-ALA-CHLOROMETHYLKETONE INHIBITOR.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PAPAIN P00784 (134-345) (PAPA1_CARPA)search Carica papayasearch 98% 212 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00784 (134 - 345) PAPAIN Carica papaya

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00784) Papain-likesearch Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P00784) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch