1p9m Summary


Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex

The structure was published by Boulanger, M.J., Chow, D.C., Brevnova, E.E., and Garcia, K.C., in 2003 in a paper entitled "Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.65 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Interleukin-6 receptor beta chain, Interleukin-6, and Interleukin-6 receptor alpha chain.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-6 receptor beta chain P40189 (23-321) (IL6RB_HUMAN)search Homo sapienssearch < 90% 299 99%
B Interleukin-6 P05231 (29-212) (IL6_HUMAN)search Homo sapienssearch 91% 186 87%
C Interleukin-6 receptor alpha chain P08887 (115-315) (IL6RA_HUMAN)search Homo sapienssearch < 90% 201 100%

This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P40189 (23 - 321) Interleukin-6 receptor beta chain Homo sapiens
P05231 (29 - 212) Interleukin-6 Homo sapiens
P08887 (115 - 315) Interleukin-6 receptor alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Fibronectin type IIIsearch Immunoglobulinssearch Fibronectin type III domainsearch, Ig-like C2-type domainsearch, Interleukin-6 receptor alpha chain, bindingsearch
B (P05231) Long-chain cytokinessearch Growth Hormone; Chain: A;search PF00489: Interleukin-6/G-CSF/MGF familysearch
C Fibronectin type IIIsearch Immunoglobulinssearch Interleukin-6 receptor alpha chain, bindingsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
B (P05231) extracellular regionsearch immune responsesearch interleukin-6 receptor bindingsearch cytokine activitysearch
C (P08887) membranesearch cytokine receptor activitysearch

Chain InterPro annotation
A Fibronectin type IIIsearch Immunoglobulin C2-set-like, ligand-bindingsearch Immunoglobulin-like foldsearch Interleukin-6 receptor alpha, bindingsearch
B Interleukin-6/Interleukin-23/GCSF/MGFsearch Interleukin-6search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
C Long hematopoietin receptor, soluble alpha chain, conserved sitesearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch Interleukin-6 receptor alpha, bindingsearch