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Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex

Source organism: Homo sapiens
Biochemical function: cytokine receptor activity
Biological process: cell differentiation
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF09240
Domain description: Interleukin-6 receptor alpha chain, binding
Occurring in:
  1. Interleukin-6 receptor subunit beta
  2. Soluble interleukin-6 receptor subunit alpha
The deposited structure of PDB entry 1p9m contains 1 copy of Pfam domain PF09240 (Interleukin-6 receptor alpha chain, binding) in Interleukin-6 receptor subunit beta. Showing 1 copy in chain A.
The deposited structure of PDB entry 1p9m contains 1 copy of Pfam domain PF09240 (Interleukin-6 receptor alpha chain, binding) in Soluble interleukin-6 receptor subunit alpha. Showing 1 copy in chain C.

PF00489
Domain description: Interleukin-6/G-CSF/MGF family
Occurring in:
  1. Interleukin-6
The deposited structure of PDB entry 1p9m contains 1 copy of Pfam domain PF00489 (Interleukin-6/G-CSF/MGF family) in Interleukin-6. Showing 1 copy in chain B.

PF00041
Domain description: Fibronectin type III domain
Occurring in:
  1. Interleukin-6 receptor subunit beta
The deposited structure of PDB entry 1p9m contains 1 copy of Pfam domain PF00041 (Fibronectin type III domain) in Interleukin-6 receptor subunit beta. Showing 1 copy in chain A.

PF06328
Domain description: Ig-like C2-type domain
Occurring in:
  1. Interleukin-6 receptor subunit beta
The deposited structure of PDB entry 1p9m contains 1 copy of Pfam domain PF06328 (Ig-like C2-type domain) in Interleukin-6 receptor subunit beta. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003961
Domain description: Fibronectin type III
Occurring in:
  1. Interleukin-6 receptor subunit beta
  2. Soluble interleukin-6 receptor subunit alpha
IPR030474
Domain description: Interleukin-6/GCSF/MGF
Occurring in:
  1. Interleukin-6
IPR036116
Domain description: Fibronectin type III superfamily
Occurring in:
  1. Interleukin-6 receptor subunit beta
  2. Soluble interleukin-6 receptor subunit alpha
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Interleukin-6 receptor subunit beta
  2. Soluble interleukin-6 receptor subunit alpha
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Interleukin-6
IPR015321
Domain description: Type I cytokine receptor, cytokine-binding domain
Occurring in:
  1. Interleukin-6 receptor subunit beta
  2. Soluble interleukin-6 receptor subunit alpha
IPR003530
Domain description: Long hematopoietin receptor, soluble alpha chain, conserved site
Occurring in:
  1. Soluble interleukin-6 receptor subunit alpha
IPR030473
Domain description: Interleukin-6/GCSF/MGF, conserved site
Occurring in:
  1. Interleukin-6
IPR003574
Domain description: Interleukin-6-like
Occurring in:
  1. Interleukin-6
IPR010457
Domain description: Immunoglobulin C2-set-like, ligand-binding
Occurring in:
  1. Interleukin-6 receptor subunit beta

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Interleukin-6 receptor subunit beta
  2. Soluble interleukin-6 receptor subunit alpha
The deposited structure of PDB entry 1p9m contains 3 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Interleukin-6 receptor subunit beta. Showing 3 copies in chain A.
The deposited structure of PDB entry 1p9m contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Soluble interleukin-6 receptor subunit alpha. Showing 2 copies in chain C.
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Interleukin-6
The deposited structure of PDB entry 1p9m contains 1 copy of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Interleukin-6. Showing 1 copy in chain B.
SCOP SCOP annotations
49266
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Fibronectin type III
Occurring in:
  1. Interleukin-6 receptor subunit beta
  2. Soluble interleukin-6 receptor subunit alpha
The deposited structure of PDB entry 1p9m contains 3 copies of SCOP domain 49266 (Fibronectin type III) in Interleukin-6 receptor subunit beta. Showing 3 copies in chain A.
The deposited structure of PDB entry 1p9m contains 2 copies of SCOP domain 49266 (Fibronectin type III) in Soluble interleukin-6 receptor subunit alpha. Showing 2 copies in chain C.
47267
Class: All alpha proteins
Fold: 4-helical cytokines
Superfamily: 4-helical cytokines
Occurring in:
  1. Interleukin-6
The deposited structure of PDB entry 1p9m contains 1 copy of SCOP domain 47267 (Long-chain cytokines) in Interleukin-6. Showing 1 copy in chain B.

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