1p8j Summary

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CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN

The structure was published by Henrich, S., Cameron, A., Bourenkov, G.P., et al., Lindberg, I., Bode, W., and Than, M.E., in 2003 in a paper entitled "The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Furin precursor and DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE INHIBITOR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Furin precursor P23188 (108-578) (FURIN_MOUSE)search Mus musculussearch < 90% 471 99%
B Furin precursor P23188 (108-578) (FURIN_MOUSE)search Mus musculussearch < 90% 471 99%
C Furin precursor P23188 (108-578) (FURIN_MOUSE)search Mus musculussearch < 90% 471 99%
D Furin precursor P23188 (108-578) (FURIN_MOUSE)search Mus musculussearch < 90% 471 99%
E Furin precursor P23188 (108-578) (FURIN_MOUSE)search Mus musculussearch < 90% 471 99%
F Furin precursor P23188 (108-578) (FURIN_MOUSE)search Mus musculussearch < 90% 471 99%
G Furin precursor P23188 (108-578) (FURIN_MOUSE)search Mus musculussearch < 90% 471 99%
H Furin precursor P23188 (108-578) (FURIN_MOUSE)search Mus musculussearch < 90% 471 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23188 (108 - 578) Furin precursor Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H Proprotein convertase P-domainsearch, Subtilasessearch Rossmann foldsearch, Galactose-binding domain-likesearch Subtilase familysearch, Proprotein convertase P-domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D, E, F, G, H (P23188) serine-type endopeptidase activitysearch proteolysissearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Peptidase S8/S53 domainsearch Proprotein convertase, Psearch Galactose-binding domain-likesearch Peptidase S8, subtilisin-relatedsearch Peptidase S8, subtilisin, His-active sitesearch Peptidase S8, subtilisin, Asp-active sitesearch Peptidase S8, subtilisin, Ser-active sitesearch