1p7l Summary

pdbe.org/1p7l
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S-Adenosylmethionine synthetase complexed with AMPPNP and Met.

The structure was published by Komoto, J., Yamada, T., Takata, Y., Markham, G.D., and Takusagawa, F., in 2004 in a paper entitled "Crystal structure of the s-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of S-adenosylmethionine synthetase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S-adenosylmethionine synthetase P0A817 (2-384) (METK_ECOLI)search Escherichia coli K-12search 100% 383 100%
B S-adenosylmethionine synthetase P0A817 (2-384) (METK_ECOLI)search Escherichia coli K-12search 100% 383 100%
C S-adenosylmethionine synthetase P0A817 (2-384) (METK_ECOLI)search Escherichia coli K-12search 100% 383 100%
D S-adenosylmethionine synthetase P0A817 (2-384) (METK_ECOLI)search Escherichia coli K-12search 100% 383 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A817 (2 - 384) S-adenosylmethionine synthetase Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P0A817) S-adenosylmethionine synthetasesearch GMP Synthetase; Chain A, domain 3search PF00438: S-adenosylmethionine synthetase, N-terminal domainsearch, PF02772: S-adenosylmethionine synthetase, central domainsearch, PF02773: S-adenosylmethionine synthetase, C-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P0A817) potassium ion bindingsearch magnesium ion bindingsearch protein bindingsearch metal ion bindingsearch methionine adenosyltransferase activitysearch ATP bindingsearch identical protein bindingsearch transferase activitysearch nucleotide bindingsearch cytosolsearch cytoplasmsearch S-adenosylmethionine cyclesearch one-carbon metabolic processsearch S-adenosylmethionine biosynthetic processsearch

Chain InterPro annotation
A, B, C, D S-adenosylmethionine synthetasesearch S-adenosylmethionine synthetase, N-terminalsearch S-adenosylmethionine synthetase, central domainsearch S-adenosylmethionine synthetase, C-terminalsearch S-adenosylmethionine synthetase, conserved sitesearch S-adenosylmethionine synthetase superfamilysearch