1p7i Summary

pdbe.org/1p7i
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CRYSTAL STRUCTURE OF ENGRAILED HOMEODOMAIN MUTANT K52A

The structure was published by Stollar, E.J., Mayor, U., Lovell, S.C., et al., Freund, S.M., Fersht, A.R., and Luisi, B.F., in 2003 in a paper entitled "Crystal Structures of Engrailed Homeodomain Mutants: IMPLICATIONS FOR STABILITY AND DYNAMICS" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Segmentation polarity homeobox protein engrailed.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Segmentation polarity homeobox protein engrailed P02836 (454-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 59 94%
B Segmentation polarity homeobox protein engrailed P02836 (454-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 59 94%
C Segmentation polarity homeobox protein engrailed P02836 (454-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 59 94%
D Segmentation polarity homeobox protein engrailed P02836 (454-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 59 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02836 (454 - 512) Segmentation polarity homeobox protein engrailed Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Homeodomainsearch Homeodomain-likesearch Homeobox domainsearch, Engrailed homeobox C-terminal signature domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D (P02836) DNA bindingsearch sequence-specific DNA bindingsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B, C, D Helix-turn-helix motifsearch Homeobox domainsearch Homeodomain-likesearch Homeobox, conserved sitesearch Homeodomain, metazoasearch