1p7c Summary


Crystal Structure of HSV1-TK complexed with TP5A

The structure was published by Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M., and Lavie, A., in 2003 in a paper entitled "Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Thymidine kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Thymidine kinase P03176 (34-376) (KITH_HHV11)search Herpes simplex virus (type 1 / strain 17)search 91% 343 92%
B Thymidine kinase P03176 (34-376) (KITH_HHV11)search Herpes simplex virus (type 1 / strain 17)search 91% 343 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03176 (34 - 376) Thymidine kinase Herpes simplex virus (type 1 / strain 17)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P03176) Nucleotide and nucleoside kinasessearch P-loop containing nucleotide triphosphate hydrolasessearch PF00693: Thymidine kinase from herpesvirussearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P03176) ATP bindingsearch thymidine kinase activitysearch transferase activitysearch kinase activitysearch nucleotide bindingsearch phosphorylationsearch DNA replicationsearch TMP biosynthetic processsearch

Chain InterPro annotation
A, B Herpesvirus thymidine kinasesearch P-loop containing nucleoside triphosphate hydrolasesearch