1p5f Summary


Crystal Structure of Human DJ-1

The structure was published by Wilson, M.A., Collins, J.L., Hod, Y., Ringe, D., and Petsko, G.A., in 2003 in a paper entitled "The 1.1 A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.1 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of RNA-binding protein regulatory subunit. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 189 residues which is 100% of the natural sequence. Out of 189 residues 186 were observed and are deposited in the PDB.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RNA-binding protein regulatory subunit Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 189 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) RNA-binding protein regulatory subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q99497) DJ-1/PfpIsearch Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q99497) scaffold protein bindingsearch enzyme bindingsearch protein bindingsearch glyoxalase III activitysearch repressing transcription factor bindingsearch androgen receptor bindingsearch core promoter bindingsearch identical protein bindingsearch transcription coactivator activitysearch ubiquitin-specific protease bindingsearch protein homodimerization activitysearch small protein conjugating enzyme bindingsearch cuprous ion bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch RNA bindingsearch small protein activating enzyme bindingsearch double-stranded DNA bindingsearch peroxiredoxin activitysearch cytokine bindingsearch superoxide dismutase copper chaperone activitysearch peptidase activitysearch receptor bindingsearch transcription factor bindingsearch cupric ion bindingsearch hydrolase activitysearch peroxidase activitysearch L-dopa decarboxylase activator activitysearch mRNA bindingsearch glyoxalase (glycolic acid-forming) activitysearch single-stranded DNA bindingsearch tyrosine 3-monooxygenase activator activitysearch nucleussearch cytosolsearch cytoplasmsearch membranesearch mitochondrionsearch axonsearch plasma membranesearch extracellular vesicular exosomesearch mitochondrial respiratory chain complex Isearch chromatinsearch PML bodysearch negative regulation of protein bindingsearch oxidation-reduction processsearch cellular response to hydrogen peroxidesearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of L-dopa decarboxylase activitysearch synaptic transmission, dopaminergicsearch single fertilizationsearch negative regulation of ubiquitin-protein transferase activitysearch regulation of androgen receptor signaling pathwaysearch cellular response to reactive oxygen speciessearch cellular response to oxidative stresssearch positive regulation of dopamine biosynthetic processsearch regulation of mitochondrial membrane potentialsearch positive regulation of peptidyl-serine phosphorylationsearch negative regulation of proteasomal ubiquitin-dependent protein catabolic processsearch negative regulation of protein export from nucleussearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch membrane depolarizationsearch autophagysearch negative regulation of cell deathsearch protein stabilizationsearch response to stresssearch negative regulation of protein ubiquitinationsearch negative regulation of protein K48-linked deubiquitinationsearch negative regulation of apoptotic processsearch lactate biosynthetic processsearch negative regulation of protein acetylationsearch regulation of inflammatory responsesearch positive regulation of tyrosine 3-monooxygenase activitysearch positive regulation of sequence-specific DNA binding transcription factor activitysearch negative regulation of death-inducing signaling complex assemblysearch negative regulation of hydrogen peroxide-induced cell deathsearch negative regulation of neuron deathsearch negative regulation of hydrogen peroxide-induced neuron deathsearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch negative regulation of protein phosphorylationsearch regulation of TRAIL receptor biosynthetic processsearch adult locomotory behaviorsearch cell deathsearch negative regulation of ubiquitin-specific protease activitysearch mitochondrion organizationsearch negative regulation of protein kinase activitysearch negative regulation of protein sumoylationsearch negative regulation of gene expressionsearch response to hydrogen peroxidesearch positive regulation of pyrroline-5-carboxylate reductase activitysearch positive regulation of androgen receptor activitysearch Ras protein signal transductionsearch inflammatory responsesearch proteolysissearch positive regulation of protein homodimerization activitysearch positive regulation of interleukin-8 productionsearch positive regulation of protein localization to nucleussearch hydrogen peroxide metabolic processsearch negative regulation of neuron apoptotic processsearch positive regulation of protein kinase B signalingsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch glycolate biosynthetic processsearch positive regulation of L-dopa biosynthetic processsearch positive regulation of gene expressionsearch positive regulation of oxidative phosphorylation uncoupler activitysearch activation of protein kinase B activitysearch regulation of neuron apoptotic processsearch regulation of fibril organizationsearch membrane hyperpolarizationsearch glyoxal catabolic processsearch positive regulation of transcription regulatory region DNA bindingsearch cellular response to glyoxalsearch negative regulation of oxidative stress-induced cell deathsearch methylglyoxal catabolic process to D-lactatesearch negative regulation of extrinsic apoptotic signaling pathwaysearch dopamine uptake involved in synaptic transmissionsearch positive regulation of superoxide dismutase activitysearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch