1p5e Summary

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The strucure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)

The structure was published by De Moliner, E., Brown, N.R., and Johnson, L.N., in 2003 in a paper entitled "Alternative binding modes of an inhibitor to two different kinases" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cell division protein kinase 2 and Cyclin A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 99%
C Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 99%
B Cyclin A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
D Cyclin A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens
P20248 (175 - 432) Cyclin A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P24941) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch histone kinase activitysearch cyclin bindingsearch transferase activitysearch protein serine/threonine kinase activitysearch metal ion bindingsearch nucleotide bindingsearch transcription factor complexsearch cytoplasmsearch microtubule organizing centersearch nucleoplasmsearch cytosolsearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch condensed chromosomesearch centrosomesearch endosomesearch cytoskeletonsearch nucleussearch chromosome, telomeric regionsearch Y chromosomesearch DNA replicationsearch cellular response to nitric oxidesearch phosphorylationsearch meiotic nuclear divisionsearch histone phosphorylationsearch G2/M transition of mitotic cell cyclesearch blood coagulationsearch mitotic nuclear divisionsearch regulation of gene silencingsearch mitotic cell cyclesearch DNA repairsearch potassium ion transportsearch G1/S transition of mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch protein phosphorylationsearch centrosome duplicationsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell divisionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch positive regulation of cell proliferationsearch cellular response to DNA damage stimulussearch positive regulation of transcription, DNA-templatedsearch cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch Ras protein signal transductionsearch
B, D (P20248) protein kinase bindingsearch nucleussearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cell cyclesearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch