1p49 Summary

pdbe.org/1p49
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Structure of Human Placental Estrone/DHEA Sulfatase

The structure was published by Hernandez-Guzman, F.G., Higashiyama, T., Pangborn, W., Osawa, Y., and Ghosh, D., in 2003 in a paper entitled "Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of STERYL-SULFATASE. This molecule has the UniProt identifier P08842 (STS_HUMAN)search. The sample contained 562 residues which is 100% of the natural sequence. Out of 562 residues 549 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A STERYL-SULFATASE P08842 (22-583) (STS_HUMAN)search Homo sapienssearch 100% 562 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08842 (22 - 583) STERYL-SULFATASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P08842) Arylsulfatasesearch Alkaline Phosphatase, subunit Asearch, Helix hairpin binsearch, Arylsulfatase, C-terminal domainsearch PF00884: Sulfatasesearch, PF14707: C-terminal region of aryl-sulfatasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P08842) metabolic processsearch small molecule metabolic processsearch steroid catabolic processsearch cellular protein metabolic processsearch lipid metabolic processsearch glycosphingolipid metabolic processsearch female pregnancysearch post-translational protein modificationsearch epidermis developmentsearch steroid metabolic processsearch sphingolipid metabolic processsearch membranesearch lysosomesearch intracellular membrane-bounded organellesearch endoplasmic reticulumsearch plasma membranesearch integral component of membranesearch endosomesearch endoplasmic reticulum membranesearch Golgi apparatussearch endoplasmic reticulum lumensearch steryl-sulfatase activitysearch metal ion bindingsearch hydrolase activitysearch sulfuric ester hydrolase activitysearch catalytic activitysearch

Chain InterPro annotation
A Sulfatasesearch Alkaline phosphatase-like, alpha/beta/alphasearch Alkaline-phosphatase-like, core domainsearch Sulfatase, conserved sitesearch