1p49 Summary


Structure of Human Placental Estrone/DHEA Sulfatase

The structure was published by Hernandez-Guzman, F.G., Higashiyama, T., Pangborn, W., Osawa, Y., and Ghosh, D., in 2003 in a paper entitled "Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of STERYL-SULFATASE. This molecule has the UniProt identifier P08842 (STS_HUMAN)search. The sample contained 562 residues which is 100% of the natural sequence. Out of 562 residues 549 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A STERYL-SULFATASE P08842 (22-583) (STS_HUMAN)search Homo sapienssearch 100% 562 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08842 (22 - 583) STERYL-SULFATASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P08842) Arylsulfatasesearch Alkaline Phosphatase, subunit Asearch, Helix hairpin binsearch, Arylsulfatase, C-terminal domainsearch PF00884: Sulfatasesearch, PF14707: C-terminal region of aryl-sulfatasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P08842) steryl-sulfatase activitysearch hydrolase activitysearch metal ion bindingsearch sulfuric ester hydrolase activitysearch catalytic activitysearch endoplasmic reticulum membranesearch integral component of membranesearch lysosomesearch membranesearch endoplasmic reticulumsearch intracellular membrane-bounded organellesearch plasma membranesearch endoplasmic reticulum lumensearch endosomesearch Golgi apparatussearch lipid metabolic processsearch steroid catabolic processsearch small molecule metabolic processsearch cellular protein metabolic processsearch epidermis developmentsearch glycosphingolipid metabolic processsearch female pregnancysearch post-translational protein modificationsearch steroid metabolic processsearch sphingolipid metabolic processsearch metabolic processsearch

Chain InterPro annotation
A Sulfatasesearch Alkaline phosphatase-like, alpha/beta/alphasearch Alkaline-phosphatase-like, core domainsearch Sulfatase, conserved sitesearch