1p3d Summary


Crystal Structure of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) in Complex with UMA and ANP.

The structure was published by Mol, C.D., Brooun, A., Dougan, D.R., et al., Knuth, M.W., McRee, D.E., and Swanson, R.V., in 2003 in a paper entitled "Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of UDP-N-acetylmuramate--alanine ligase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A UDP-N-acetylmuramate--alanine ligase P45066 (1-475) (MURC_HAEIN)search Haemophilus influenzae Rd KW20search 100% 475 97%
B UDP-N-acetylmuramate--alanine ligase P45066 (1-475) (MURC_HAEIN)search Haemophilus influenzae Rd KW20search 100% 475 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P45066 (1 - 475) UDP-N-acetylmuramate--alanine ligase Haemophilus influenzae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P45066) MurCD N-terminal domainsearch, MurCDEF C-terminal domainsearch, MurCDEFsearch NAD(P)-binding Rossmann-like Domainsearch, UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligasesearch, Protein-Tyrosine Phosphatase; Chain Asearch PF01225: Mur ligase family, catalytic domainsearch, PF02875: Mur ligase family, glutamate ligase domainsearch, PF08245: Mur ligase middle domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P45066) ATP bindingsearch ligase activitysearch UDP-N-acetylmuramate-L-alanine ligase activitysearch nucleotide bindingsearch regulation of cell shapesearch cell divisionsearch peptidoglycan biosynthetic processsearch cell cyclesearch cell wall organizationsearch biosynthetic processsearch cytoplasmsearch

Chain InterPro annotation
A, B Mur ligase, N-terminalsearch Mur ligase, C-terminalsearch UDP-N-acetylmuramate-alanine ligasesearch Mur ligase, centralsearch NAD(P)-binding domainsearch