1p38 Summary



The structure was published by Wang, Z., Harkins, P.C., Ulevitch, R.J., Han, J., Cobb, M.H., and Goldsmith, E.J., in 1997 in a paper entitled "The structure of mitogen-activated protein kinase p38 at 2.1-A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MAP KINASE P38. This molecule has the UniProt identifier P47811 (MK14_MOUSE)search. The sample contained 379 residues which is 100% of the natural sequence. Out of 379 residues 351 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP KINASE P38 P47811 (1-360) (MK14_MOUSE)search Mus musculussearch 97% 379 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47811 (1 - 360) MAP KINASE P38 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47811) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P47811) protein phosphorylationsearch intracellular signal transductionsearch cartilage condensationsearch p38MAPK cascadesearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of myoblast differentiationsearch response to lipopolysaccharidesearch positive regulation of protein import into nucleussearch positive regulation of myoblast fusionsearch positive regulation of transcription from RNA polymerase II promotersearch angiogenesissearch regulation of transcription, DNA-templatedsearch striated muscle cell differentiationsearch transcription, DNA-templatedsearch chondrocyte differentiationsearch fatty acid oxidationsearch cellular response to DNA damage stimulussearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch apoptotic processsearch signal transduction in response to DNA damagesearch peptidyl-serine phosphorylationsearch glucose metabolic processsearch phosphorylationsearch cellular response to vascular endothelial growth factor stimulussearch stress-induced premature senescencesearch negative regulation of canonical Wnt signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch osteoclast differentiationsearch cellular response to ionizing radiationsearch positive regulation of erythrocyte differentiationsearch DNA damage checkpointsearch lipopolysaccharide-mediated signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch skeletal muscle tissue developmentsearch response to stresssearch cell morphogenesissearch cellular response to lipopolysaccharidesearch positive regulation of myotube differentiationsearch response to muramyl dipeptidesearch protein bindingsearch kinase activitysearch transferase activitysearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch MAP kinase activitysearch NFAT protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch nucleussearch cytosolsearch cytoplasmsearch mitochondrionsearch spindle polesearch cellsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch