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PDBe Entry: 1p22 view

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase
Summary
Header SIGNALING PROTEINsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.95 Å, R-factor: 23.315%, Free R-factor: 28.554%, Spacegroup: P 31
Released 08/07/2003, deposition: 14/04/2003, last revision: 24/02/2009
Authors Wu, G.search; Xu, G.search; Schulman, B.A.search; Jeffrey, P.D.search; Harper, J.W.search; Pavletich, N.P.search
Primary citation Structure of a beta-TrCP1-Skp1-beta-Catenin complex: destruction motif binding and lysine specificity of the SCFbeta-TrCP1 ubiquitin ligase
MOL.CELLsearch vol:11, pag:1445-1456 (2003) [PubMed ID 12820959 ]search
Keywords Ubiquitinationsearch, degradationsearch, SIGNALING PROTEINsearch
Organism Homo sapiens(human) 9606search(A B C)
UniProt F-box/WD repeat-containing protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit) Q9Y297search (A)
S-phase kinase-associated protein 1 (Cyclin A/CDK2-associated protein p19) (p19skp1) (p19A) (RNA polymerase II elongation factor-like protein) (Organ of Corti protein 2) (OCP-2) (OCP-II) (Transcription elongation factor B) (SIII) P63208search (B)
Catenin beta-1 (Beta-catenin) P35222search (C)
Polymers
Id Name Type UniProt Residues Observed
A F-box/WD-repeat protein 1A Protein Q9Y297 (FBW1A_HUMAN)search
435 92%
B Skp1 Protein P63208 (SKP1_HUMAN)search
145 90%
C Beta-catenin Protein P35222 (CTNB1_HUMAN)search
26 42%
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