1p22 Summary


Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase

The structure was published by Wu, G., Xu, G., Schulman, B.A., Jeffrey, P.D., Harper, J.W., and Pavletich, N.P., in 2003 in a paper entitled "Structure of a beta-TrCP1-Skp1-beta-Catenin complex: destruction motif binding and lysine specificity of the SCFbeta-TrCP1 ubiquitin ligase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.95 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely F-box/WD-repeat protein 1A, Skp1, and Beta-catenin.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A F-box/WD-repeat protein 1A Q9Y297 (175-605) (FBW1A_HUMAN)search Homo sapienssearch < 90% 435 92%
B Skp1 P63208 (1-163) (SKP1_HUMAN)search Homo sapienssearch 98% 145 90%
C Beta-catenin P35222 (19-44) (CTNB1_HUMAN)search Homo sapienssearch < 90% 26 42%

This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9Y297 (175 - 605) F-box/WD-repeat protein 1A Homo sapiens
P63208 (1 - 163) Skp1 Homo sapiens
P35222 (19 - 44) Beta-catenin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A F-box domainsearch, WD40-repeatsearch Monooxygenasesearch, YVTN repeat-like/Quinoprotein amine dehydrogenasesearch WD domain, G-beta repeatsearch, D domain of beta-TrCPsearch, F-box-likesearch
B (P63208) Skp1 dimerisation domain-likesearch, BTB/POZ domainsearch Potassium Channel Kv1.1; Chain Asearch PF01466: Skp1 family, dimerisation domainsearch, PF03931: Skp1 family, tetramerisation domainsearch

Chain ID Biological process (GO)
B (P63208) ubiquitin-dependent protein catabolic processsearch

Chain InterPro annotation
A WD40 repeatsearch F-box domainsearch WD40/YVTN repeat-like-containing domainsearch WD40-repeat-containing domainsearch WD40 repeat, conserved sitesearch G-protein beta WD-40 repeatsearch
B SKP1 componentsearch BTB/POZ foldsearch SKP1 component, dimerisationsearch SKP1 component, POZ domainsearch E3 ubiquitin ligase, SCF complex, Skp subunitsearch