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Comparison of class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase determined at 0.99 Angstrom resolution

Source organism: Escherichia coli K-12
Biochemical function: lyase activity
Biological process: deoxyribose phosphate catabolic process
Cellular component: membrane

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EC 4.1.2.4: Deoxyribose-phosphate aldolase

Reaction catalysed:
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
Systematic name:
2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)
Alternative Name(s):
  • 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase
  • 2-deoxyribose-5-phosphate aldolase
  • Deoxyriboaldolase
  • Deoxyribose-5-phosphate aldolase
  • Phosphodeoxyriboaldolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01791
Domain description: DeoC/LacD family aldolase
Occurring in:
  1. Deoxyribose-phosphate aldolase
The deposited structure of PDB entry 1p1x contains 2 copies of Pfam domain PF01791 (DeoC/LacD family aldolase) in Deoxyribose-phosphate aldolase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR011343
Domain description: Deoxyribose-phosphate aldolase
Occurring in:
  1. Deoxyribose-phosphate aldolase
IPR002915
Domain description: DeoC/FbaB/LacD aldolase
Occurring in:
  1. Deoxyribose-phosphate aldolase
IPR023649
Domain description: Deoxyribose-phosphate aldolase type II
Occurring in:
  1. Deoxyribose-phosphate aldolase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Deoxyribose-phosphate aldolase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Deoxyribose-phosphate aldolase
The deposited structure of PDB entry 1p1x contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Deoxyribose-phosphate aldolase. Showing 1 copy in chain B.
SCOP SCOP annotation
51570
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Occurring in:
  1. Deoxyribose-phosphate aldolase
The deposited structure of PDB entry 1p1x contains 2 copies of SCOP domain 51570 (Class I aldolase) in Deoxyribose-phosphate aldolase. Showing 1 copy in chain B.

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