1ozs Summary

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C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I

The structure was published by Lindhout, D.A. and Sykes, B.D., in 2003 in a paper entitled "Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Troponin C, slow skeletal and cardiac muscles and Troponin I, cardiac muscle.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Troponin C, slow skeletal and cardiac muscles P63316 (90-161) (TNNC1_HUMAN)search Homo sapienssearch 100% 73 100%
B Troponin I, cardiac muscle P19429 (129-148) (TNNI3_HUMAN)search Homo sapienssearch < 90% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P63316 (90 - 161) Troponin C, slow skeletal and cardiac muscles Homo sapiens
P19429 (129 - 148) Troponin I, cardiac muscle Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P63316) Calmodulin-likesearch EF-handsearch PF13499: EF-hand domain pairsearch
B Troponinsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P63316) calcium ion bindingsearch
B (P19429) troponin complexsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B Troponinsearch