1oz1 Summary

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P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR

The structure was published by Trejo, A., Arzeno, H., Browner, M., et al., Whiteley, P.E., Zeng, L., and Goldstein, D.M., in 2003 in a paper entitled "Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 344 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q16539) nucleoplasmsearch cytosolsearch mitochondrionsearch nucleussearch cytoplasmsearch spindle polesearch cellsearch extracellular vesicular exosomesearch toll-like receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch positive regulation of protein import into nucleussearch positive regulation of myoblast differentiationsearch regulation of transcription from RNA polymerase II promotersearch intracellular signal transductionsearch p38MAPK cascadesearch mRNA metabolic processsearch positive regulation of muscle cell differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch glucose metabolic processsearch protein phosphorylationsearch myoblast differentiation involved in skeletal muscle regenerationsearch Ras protein signal transductionsearch response to lipopolysaccharidesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch RNA metabolic processsearch toll-like receptor 10 signaling pathwaysearch transcription, DNA-templatedsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of myoblast fusionsearch chemotaxissearch fatty acid oxidationsearch toll-like receptor 4 signaling pathwaysearch cellular response to ionizing radiationsearch osteoclast differentiationsearch TRIF-dependent toll-like receptor signaling pathwaysearch cellular component movementsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of blood vessel endothelial cell migrationsearch muscle cell differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch skeletal muscle tissue developmentsearch DNA damage checkpointsearch regulation of transcription, DNA-templatedsearch response to muramyl dipeptidesearch toll-like receptor 2 signaling pathwaysearch cartilage condensationsearch response to stresssearch innate immune responsesearch cell morphogenesissearch apoptotic processsearch positive regulation of myotube differentiationsearch cellular response to lipopolysaccharidesearch striated muscle cell differentiationsearch platelet activationsearch stress-induced premature senescencesearch cellular response to DNA damage stimulussearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch signal transductionsearch angiogenesissearch cell surface receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch activation of MAPK activitysearch signal transduction in response to DNA damagesearch blood coagulationsearch phosphorylationsearch toll-like receptor 3 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor 5 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch stress-activated MAPK cascadesearch positive regulation of erythrocyte differentiationsearch chondrocyte differentiationsearch gene expressionsearch cellular response to vascular endothelial growth factor stimulussearch MAP kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch ATP bindingsearch transferase activitysearch kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch