1oy3 Summary

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CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX

The structure was published by Malek, S., Huang, D.B., Huxford, T., Ghosh, S., and Ghosh, G., in 2003 in a paper entitled "X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Transcription factor p65 and transcription factor inhibitor I-kappa-B-beta.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C Transcription factor p65 Q04207 (191-326) (TF65_MOUSE)search Mus musculussearch < 90% 136 99%
B Transcription factor p65 Q04207 (191-326) (TF65_MOUSE)search Mus musculussearch < 90% 136 99%
D transcription factor inhibitor I-kappa-B-beta Q60778 (50-331) (IKBB_MOUSE)search Mus musculussearch < 90% 282 78%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q04207 (191 - 326) Transcription factor p65 Mus musculus
Q60778 (50 - 331) transcription factor inhibitor I-kappa-B-beta Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C, B NF-kappa-B/REL/DORSAL transcription factors, C-terminal domainsearch Immunoglobulinssearch
D Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch Ankyrin repeatsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
C, B (Q04207) nucleussearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
C, B NF-kappa-B/Rel/Dorsalsearch IPT domainsearch Immunoglobulin-like foldsearch Immunoglobulin E-setsearch
D Ankyrin repeatsearch Ankyrin repeat-containing domainsearch