1owt Summary

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain

The structure was published by Barnham, K.J., McKinstry, W.J., Multhaup, G., et al., Masters, C.L., Parker, M.W., and Cappai, R., in 2003 in a paper entitled "Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain. A REGULATOR OF NEURONAL COPPER HOMEOSTASIS." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Amyloid beta A4 protein. This molecule has the UniProt identifier P05067 (A4_HUMAN)search. The sample contained 66 residues which is < 90% of the natural sequence. Out of 66 residues 66 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Amyloid beta A4 protein P05067 (124-189) (A4_HUMAN)search Homo sapienssearch < 90% 66 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05067 (124 - 189) Amyloid beta A4 protein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Amyloid beta a4 protein copper binding domain (domain 2)search Amyloid beta a4 protein copper binding domainsearch Amyloid A4 N-terminal heparin-bindingsearch, Copper-binding of amyloid precursor, CuBDsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P05067) nervous system developmentsearch transition metal ion bindingsearch

Chain InterPro annotation
A Amyloidogenic glycoprotein, copper-bindingsearch Amyloidogenic glycoprotein, extracellular domain conserved sitesearch Amyloid beta A4 proteinsearch