1ovl Summary

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Crystal Structure of Nurr1 LBD

The structure was published by Wang, Z., Benoit, G., Liu, J., et al., Xu, H., Walker, N., and Perlmann, T., in 2003 in a paper entitled "Structure and Function of Nurr1 identifies a Class of Ligand-Independent Nuclear Receptors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Orphan nuclear receptor NURR1 (MSE 414, 496, 511) and Orphan nuclear receptor NURR1 (MSE 496, 511).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Orphan nuclear receptor NURR1 (MSE 414, 496, 511) P43354 (328-598) (NR4A2_HUMAN)search Homo sapienssearch < 90% 271 84%
D Orphan nuclear receptor NURR1 (MSE 414, 496, 511) P43354 (328-598) (NR4A2_HUMAN)search Homo sapienssearch < 90% 271 84%
B Orphan nuclear receptor NURR1 (MSE 496, 511) P43354 (328-598) (NR4A2_HUMAN)search Homo sapienssearch < 90% 271 92%
C Orphan nuclear receptor NURR1 (MSE 496, 511) P43354 (328-598) (NR4A2_HUMAN)search Homo sapienssearch < 90% 271 92%
E Orphan nuclear receptor NURR1 (MSE 496, 511) P43354 (328-598) (NR4A2_HUMAN)search Homo sapienssearch < 90% 271 92%
F Orphan nuclear receptor NURR1 (MSE 496, 511) P43354 (328-598) (NR4A2_HUMAN)search Homo sapienssearch < 90% 271 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P43354 (328 - 598) Orphan nuclear receptor NURR1 (MSE 414, 496, 511) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Zinc finger, C4 type (two domains)search
B, C, E, F Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Zinc finger, C4 type (two domains)search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, D (P43354) sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch steroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch
B, C, E, F (P43354) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Orphan nuclear receptorsearch Orphan nuclear receptor, NURR typesearch Nuclear hormone receptor, ligand-bindingsearch
B, C, E, F Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Orphan nuclear receptorsearch Orphan nuclear receptor, NURR typesearch Nuclear hormone receptor, ligand-bindingsearch