1ove Summary


The structure of p38 alpha in complex with a dihydroquinolinone

The structure was published by Fitzgerald, C.E., Patel, S.B., Becker, J.W., et al., Pikounis, V.B., O'Keefe, S.J., and Scapin, G., in 2003 in a paper entitled "Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 348 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch kinase activitysearch protein bindingsearch ATP bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch MAP kinase kinase activitysearch transferase activitysearch protein phosphorylationsearch chemotaxissearch positive regulation of myoblast fusionsearch response to stresssearch TRIF-dependent toll-like receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch transcription, DNA-templatedsearch cartilage condensationsearch positive regulation of myoblast differentiationsearch vascular endothelial growth factor receptor signaling pathwaysearch angiogenesissearch positive regulation of erythrocyte differentiationsearch activation of MAPK activitysearch Ras protein signal transductionsearch toll-like receptor 4 signaling pathwaysearch regulation of transcription, DNA-templatedsearch regulation of transcription from RNA polymerase II promotersearch positive regulation of blood vessel endothelial cell migrationsearch signal transduction in response to DNA damagesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch muscle cell differentiationsearch cell morphogenesissearch fatty acid oxidationsearch glucose metabolic processsearch p38MAPK cascadesearch cellular component movementsearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch peptidyl-serine phosphorylationsearch lipopolysaccharide-mediated signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch apoptotic processsearch cell surface receptor signaling pathwaysearch chondrocyte differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor signaling pathwaysearch intracellular signal transductionsearch mRNA metabolic processsearch cellular response to DNA damage stimulussearch toll-like receptor 3 signaling pathwaysearch positive regulation of muscle cell differentiationsearch striated muscle cell differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch DNA damage checkpointsearch 3'-UTR-mediated mRNA stabilizationsearch osteoclast differentiationsearch cellular response to ionizing radiationsearch response to lipopolysaccharidesearch gene expressionsearch toll-like receptor 9 signaling pathwaysearch phosphorylationsearch platelet activationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch stress-activated MAPK cascadesearch cellular response to lipopolysaccharidesearch toll-like receptor 10 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch RNA metabolic processsearch response to muramyl dipeptidesearch skeletal muscle tissue developmentsearch innate immune responsesearch blood coagulationsearch positive regulation of myotube differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch signal transductionsearch cellular response to vascular endothelial growth factor stimulussearch stress-induced premature senescencesearch nucleoplasmsearch cytoplasmsearch spindle polesearch cytosolsearch mitochondrionsearch nucleussearch extracellular vesicular exosomesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch