1ov3 Summary

pdbe.org/1ov3
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Structure of the p22phox-p47phox complex

The structure was published by Groemping, Y., Lapouge, K., Smerdon, S.J., and Rittinger, K., in 2003 in a paper entitled "Molecular basis of phosphorylation-induced activation of the NADPH oxidase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Neutrophil cytosol factor 1 and Flavocytochrome b558 alpha polypeptide.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Neutrophil cytosol factor 1 P14598 (156-285) (NCF1_HUMAN)search Homo sapienssearch < 90% 138 97%
B Neutrophil cytosol factor 1 P14598 (156-285) (NCF1_HUMAN)search Homo sapienssearch < 90% 138 97%
C Flavocytochrome b558 alpha polypeptide Not available
Synthetic Not available 18 61%
D Flavocytochrome b558 alpha polypeptide Not available
Synthetic Not available 18 61%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14598 (156 - 285) Neutrophil cytosol factor 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SH3-domainsearch SH3 Domainssearch SH3 domainsearch
C, D

Chain ID Molecular function (GO) Cellular component (GO)
A, B (P14598) superoxide-generating NADPH oxidase activitysearch cytoplasmsearch

Chain InterPro annotation
A, B Src homology-3 domainsearch Neutrophil cytosol factor 1search
C, D