1ouk Summary


The structure of p38 alpha in complex with a pyridinylimidazole inhibitor

The structure was published by Fitzgerald, C.E., Patel, S.B., Becker, J.W., et al., Pikounis, V.B., O'Keefe, S.J., and Scapin, G., in 2003 in a paper entitled "Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 347 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch ATP bindingsearch protein bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch kinase activitysearch nucleotide bindingsearch NFAT protein bindingsearch MAP kinase kinase activitysearch transferase activitysearch positive regulation of transcription from RNA polymerase II promotersearch regulation of transcription from RNA polymerase II promotersearch gene expressionsearch osteoclast differentiationsearch Ras protein signal transductionsearch peptidyl-serine phosphorylationsearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor 5 signaling pathwaysearch regulation of transcription, DNA-templatedsearch stress-activated MAPK cascadesearch positive regulation of erythrocyte differentiationsearch p38MAPK cascadesearch striated muscle cell differentiationsearch response to muramyl dipeptidesearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of protein import into nucleussearch protein phosphorylationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch chemotaxissearch cellular component movementsearch mRNA metabolic processsearch phosphorylationsearch response to stresssearch myoblast differentiation involved in skeletal muscle regenerationsearch cell surface receptor signaling pathwaysearch activation of MAPK activitysearch blood coagulationsearch positive regulation of myoblast fusionsearch fatty acid oxidationsearch cellular response to DNA damage stimulussearch muscle cell differentiationsearch positive regulation of muscle cell differentiationsearch DNA damage checkpointsearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch cellular response to ionizing radiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch cellular response to lipopolysaccharidesearch lipopolysaccharide-mediated signaling pathwaysearch platelet activationsearch toll-like receptor 3 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch innate immune responsesearch signal transduction in response to DNA damagesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cell morphogenesissearch angiogenesissearch glucose metabolic processsearch RNA metabolic processsearch toll-like receptor 2 signaling pathwaysearch cartilage condensationsearch skeletal muscle tissue developmentsearch positive regulation of myoblast differentiationsearch transcription, DNA-templatedsearch MyD88-independent toll-like receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch chondrocyte differentiationsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of myotube differentiationsearch apoptotic processsearch signal transductionsearch intracellular signal transductionsearch toll-like receptor 9 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch response to lipopolysaccharidesearch nucleussearch cytoplasmsearch cytosolsearch nucleoplasmsearch extracellular vesicular exosomesearch mitochondrionsearch cellsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch