1oth Summary



The structure was published by Shi, D., Morizono, H., Ha, Y., Aoyagi, M., Tuchman, M., and Allewell, N.M., in 1998 in a paper entitled "1.85-A resolution crystal structure of human ornithine transcarbamoylase complexed with N-phosphonacetyl-L-ornithine. Catalytic mechanism and correlation with inherited deficiency." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (ORNITHINE TRANSCARBAMOYLASE). This molecule has the UniProt identifier P00480 (OTC_HUMAN)search. The sample contained 321 residues which is 91% of the natural sequence. Out of 321 residues 320 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (ORNITHINE TRANSCARBAMOYLASE) P00480 (34-354) (OTC_HUMAN)search Homo sapienssearch 91% 321 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00480) Aspartate/ornithine carbamoyltransferasesearch Rossmann foldsearch PF00185: Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domainsearch, PF02729: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00480) citrulline biosynthetic processsearch urea cyclesearch response to drugsearch response to insulinsearch ornithine metabolic processsearch response to nutrient levelssearch arginine biosynthetic processsearch cellular amino acid metabolic processsearch anion homeostasissearch cellular nitrogen compound metabolic processsearch ammonia homeostasissearch response to zinc ionsearch ornithine catabolic processsearch protein homotrimerizationsearch midgut developmentsearch response to biotinsearch small molecule metabolic processsearch liver developmentsearch cellular amino acid biosynthetic processsearch ornithine carbamoyltransferase activitysearch carboxyl- or carbamoyltransferase activitysearch amino acid bindingsearch phosphate ion bindingsearch phospholipid bindingsearch transferase activitysearch mitochondrial inner membranesearch mitochondrionsearch mitochondrial matrixsearch cytoplasmsearch

Chain InterPro annotation
A Ornithine/putrescine carbamoyltransferasesearch Aspartate/ornithine carbamoyltransferasesearch Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domainsearch Aspartate/ornithine carbamoyltransferase, carbamoyl-P bindingsearch