1osh Summary


A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

The structure was published by Downes, M., Verdecia, M.A., Roecker, A.J., et al., Noel, J.P., Nicolaou, K.C., and Evans, R.M., in 2003 in a paper entitled "A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Bile acid receptor. This molecule has the UniProt identifier Q96RI1 (NR1H4_HUMAN)search. The sample contained 232 residues which is < 90% of the natural sequence. Out of 232 residues 216 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Bile acid receptor Q96RI1 (258-486) (NR1H4_HUMAN)search Homo sapienssearch < 90% 232 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q96RI1 (258 - 486) Bile acid receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q96RI1) sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch thyroid hormone receptor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch