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A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

X-ray diffraction
1.8Å resolution
PDB entry 1osh coloured by chain, front view.
PDB entry 1osh coloured by chain, side view.
PDB entry 1osh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bile acid receptor
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Multimeric state: monomeric
Accessible surface area: 11149.3 Å2
Buried surface area: 1191.03 Å2
Dissociation area: 595.51 Å2
Dissociation energy (ΔGdiss): -5.11 kcal/mol
Dissociation entropy (TΔSdiss): 5.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188722

Macromolecules

Bile acid receptor
Chain: A
Length: 232 amino acids
Theoretical weight: 27.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RI1 (Residues: 257-486; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Bile acid receptor in PDB entry 1osh, assembly 1, front view.
Bile acid receptor in PDB entry 1osh, assembly 1, side view.
Bile acid receptor in PDB entry 1osh, assembly 1, top view.
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