1opl Summary


Structural basis for the auto-inhibition of c-Abl tyrosine kinase

The structure was published by Nagar, B., Hantschel, O., Young, M.A., et al., Clarkson, B., Superti-Furga, G., and Kuriyan, J., in 2003 in a paper entitled "Structural basis for the autoinhibition of c-Abl tyrosine kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.42 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of proto-oncogene tyrosine-protein kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A proto-oncogene tyrosine-protein kinase P00519 (27-512) (ABL1_HUMAN)search Homo sapienssearch < 90% 537 83%
B proto-oncogene tyrosine-protein kinase P00519 (27-512) (ABL1_HUMAN)search Homo sapienssearch < 90% 537 83%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00519 (27 - 512) proto-oncogene tyrosine-protein kinase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SH3-domainsearch, SH2 domainsearch, Protein kinases, catalytic subunitsearch SH3 Domainssearch, SHC Adaptor Proteinsearch, Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search SH2 domainsearch, SH3 domainsearch, Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P00519) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch SH2 domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch SH3 domainsearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch