Structural basis for the auto-inhibition of c-Abl tyrosine kinase
The structure was published by Nagar, B., Hantschel, O., Young, M.A., et al., Clarkson, B., Superti-Furga, G., and Kuriyan, J., in 2003 in a paper entitled "Structural basis for the autoinhibition of c-Abl tyrosine kinase" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase ABL1. This molecule has the UniProt identifier P00520 (ABL1_MOUSE). The sample contained 495 residues which is < 90% of the natural sequence. Out of 495 residues 449 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: