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Structural basis for the auto-inhibition of c-Abl tyrosine kinase

X-ray diffraction
1.8Å resolution
PDB entry 1opk coloured by chain, front view.
PDB entry 1opk coloured by chain, side view.
PDB entry 1opk coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase ABL1
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Multimeric state: monomeric
Accessible surface area: 21314.16 Å2
Buried surface area: 1694.91 Å2
Dissociation area: 292.27 Å2
Dissociation energy (ΔGdiss): -5.95 kcal/mol
Dissociation entropy (TΔSdiss): 3.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132624

Macromolecules

Tyrosine-protein kinase ABL1
Chain: A
Length: 495 amino acids
Theoretical weight: 56.19 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00520 (Residues: 27-515; Coverage: 44%)
Gene names: Abl, Abl1
Pfam:
InterPro:
CATH:
SCOP:
Tyrosine-protein kinase ABL1 in PDB entry 1opk, assembly 1, front view.
Tyrosine-protein kinase ABL1 in PDB entry 1opk, assembly 1, side view.
Tyrosine-protein kinase ABL1 in PDB entry 1opk, assembly 1, top view.
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