1opj Summary

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Structural basis for the auto-inhibition of c-Abl tyrosine kinase

The structure was published by Nagar, B., Hantschel, O., Young, M.A., et al., Clarkson, B., Superti-Furga, G., and Kuriyan, J., in 2003 in a paper entitled "Structural basis for the autoinhibition of c-Abl tyrosine kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase ABL1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase ABL1 P00520 (229-515) (ABL1_MOUSE)search Mus musculussearch < 90% 293 98%
B Proto-oncogene tyrosine-protein kinase ABL1 P00520 (229-515) (ABL1_MOUSE)search Mus musculussearch < 90% 293 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00520 (229 - 515) Proto-oncogene tyrosine-protein kinase ABL1 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P00520) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch