› 1oo8

X-ray diffraction
2.65Å resolution

CRYSTAL STRUCTURE OF A1PI-PITTSBURGH IN THE NATIVE CONFORMATION

Released:
DOI: 10.2210/pdb1oo8/pdb
PDB entry 1oo8 coloured by chain, front view.
PDB entry 1oo8 coloured by chain, side view.
PDB entry 1oo8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases.
Dementiev A, Simonovic M, Volz K, Gettins PG
J Biol Chem 278 37881-7 (2003)
PMID: 12860985

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01009 (Residues: 26-418; Coverage: 100%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 39.36Å b: 53.01Å c: 208.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.188 0.193
Expression system: Escherichia coli

Quick links

Citations

16 review citations

An overview of the serpin superfamily.
Law et al. (2006)
15 more