1oo4 Summary


P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase complexed to a peptide derived from PDGFr

The structure was published by Guenther, U.L., Weyrauch, B., Zhang, X., and Schaffhausen, B., in 2003 in a paper entitled "Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Phosphatidylinositol 3-kinase regulatory alpha subunit and 8-mer peptide from PDGFr.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphatidylinositol 3-kinase regulatory alpha subunit P23727 (321-431) (P85A_BOVIN)search Bos taurussearch < 90% 111 100%
B 8-mer peptide from PDGFr Not available
Synthetic Not available 8 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23727 (321 - 431) Phosphatidylinositol 3-kinase regulatory alpha subunit Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P23727) phosphatidylinositol 3-kinase regulator activitysearch phosphatidylinositol 3-kinase complexsearch

Chain InterPro annotation
A SH2 domainsearch PI3 kinase, P85 regulatory subunitsearch