1oo3 Summary


P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase

The structure was published by Guenther, U.L., Weyrauch, B., Zhang, X., and Schaffhausen, B., in 2003 in a paper entitled "Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Phosphatidylinositol 3-kinase regulatory alpha subunit. This molecule has the UniProt identifier P23727 (P85A_BOVIN)search. The sample contained 111 residues which is < 90% of the natural sequence. Out of 111 residues 110 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphatidylinositol 3-kinase regulatory alpha subunit P23727 (321-431) (P85A_BOVIN)search Bos taurussearch < 90% 111 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23727 (321 - 431) Phosphatidylinositol 3-kinase regulatory alpha subunit Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P23727) phosphatidylinositol 3-kinase regulator activitysearch phosphatidylinositol 3-kinase complexsearch

Chain InterPro annotation
A SH2 domainsearch PI3 kinase, P85 regulatory subunitsearch