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Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits

X-ray diffraction
2.5Å resolution
PDB entry 1omw coloured by chain, front view.
PDB entry 1omw coloured by chain, side view.
PDB entry 1omw coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 48365.02 Å2
Buried surface area: 6581.27 Å2
Dissociation area: 1,080.43 Å2
Dissociation energy (ΔGdiss): -1.69 kcal/mol
Dissociation entropy (TΔSdiss): 14.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149112

Macromolecules

Beta-adrenergic receptor kinase 1
Chain: A
Length: 689 amino acids
Theoretical weight: 79.75 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21146 (Residues: 1-689; Coverage: 100%)
Gene names: ADRBK1, GRK2
Pfam:
InterPro:
CATH:
SCOP:
Beta-adrenergic receptor kinase 1 in PDB entry 1omw, assembly 1, front view.
Beta-adrenergic receptor kinase 1 in PDB entry 1omw, assembly 1, side view.
Beta-adrenergic receptor kinase 1 in PDB entry 1omw, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62871 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
SCOP: WD40-repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 1omw, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 1omw, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 1omw, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 74 amino acids
Theoretical weight: 8.41 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63212 (Residues: 1-68; Coverage: 96%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
CATH: Transducin (heterotrimeric G protein), gamma chain
SCOP: Transducin (heterotrimeric G protein), gamma chain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 1omw, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 1omw, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 1omw, assembly 1, top view.
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