1ol5 Summary

pdbe.org/1ol5
spacer

STRUCTURE OF AURORA-A 122-403, PHOSPHORYLATED ON THR287, THR288 AND BOUND TO TPX2 1-43

The structure was published by Bayliss, R., Sardon, T., Vernos, I., and Conti, E., in 2003 in a paper entitled "Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SERINE/THREONINE KINASE 6 and RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE KINASE 6 O14965 (122-403) (AURKA_HUMAN)search Homo sapienssearch < 90% 282 94%
B RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100 Q9ULW0 (1-43) (TPX2_HUMAN)search Homo sapienssearch < 90% 43 69%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O14965 (122 - 403) SERINE/THREONINE KINASE 6 Homo sapiens
Q9ULW0 (1 - 43) RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search Protein kinase domainsearch
B Aurora-A bindingsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (O14965) protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch
B (Q9ULW0) mitotic nuclear divisionsearch spindlesearch microtubulesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B TPX2search Aurora-A bindingsearch