1ol1 Summary



The structure was published by Kontopidis, G., Andrews, M., Mcinnes, C., et al., Green, S., Walkinshaw, M., and Fischer, P., in 2003 in a paper entitled "Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and CIR-CIR-LEU-ILE-PFF-NH2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 298 99%
B CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%
D CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (173 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch cyclin bindingsearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch histone kinase activitysearch nucleotide bindingsearch metal ion bindingsearch protein phosphorylationsearch G1/S transition of mitotic cell cyclesearch meiotic nuclear divisionsearch mitotic cell cyclesearch mitotic nuclear divisionsearch G2/M transition of mitotic cell cyclesearch potassium ion transportsearch regulation of gene silencingsearch blood coagulationsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA repairsearch histone phosphorylationsearch Ras protein signal transductionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cellular response to nitric oxidesearch DNA replicationsearch cell cyclesearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cell divisionsearch cellular response to DNA damage stimulussearch positive regulation of transcription, DNA-templatedsearch meiotic cell cyclesearch positive regulation of cell proliferationsearch phosphorylationsearch centrosome duplicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch nucleoplasmsearch chromosome, telomeric regionsearch cytosolsearch condensed chromosomesearch nucleussearch endosomesearch cyclin-dependent protein kinase holoenzyme complexsearch transcription factor complexsearch Y chromosomesearch Cajal bodysearch cytoskeletonsearch cytoplasmsearch microtubule organizing centersearch X chromosomesearch centrosomesearch
B, D (P20248) protein kinase bindingsearch regulation of cell cyclesearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch