1okw Summary



The structure was published by Kontopidis, G., Andrews, M., Mcinnes, C., et al., Green, S., Walkinshaw, M., and Fischer, P., in 2003 in a paper entitled "Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and ACE-ARG-ARG-LEU-ASN-FCL-NH2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%
D CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (173 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P24941) protein phosphorylationsearch DNA replicationsearch centrosome duplicationsearch histone phosphorylationsearch mitotic nuclear divisionsearch DNA repairsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to DNA damage stimulussearch mitotic G1 DNA damage checkpointsearch potassium ion transportsearch Ras protein signal transductionsearch cellular response to nitric oxidesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell cyclesearch phosphorylationsearch G2/M transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch regulation of gene silencingsearch mitotic cell cyclesearch blood coagulationsearch positive regulation of cell proliferationsearch G1/S transition of mitotic cell cyclesearch meiotic nuclear divisionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch cell divisionsearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch histone kinase activitysearch kinase activitysearch nucleotide bindingsearch transferase activitysearch cyclin bindingsearch metal ion bindingsearch nucleoplasmsearch Cajal bodysearch cytosolsearch microtubule organizing centersearch cyclin-dependent protein kinase holoenzyme complexsearch endosomesearch nucleussearch condensed chromosomesearch centrosomesearch transcription factor complexsearch chromosome, telomeric regionsearch cytoplasmsearch Y chromosomesearch X chromosomesearch cytoskeletonsearch
B, D (P20248) regulation of cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch protein kinase bindingsearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch