1okm Summary

pdbe.org/1okm
spacer

CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE

The structure was published by Elbaum, D., Nair, S.K., Patchan, M.W., Thompson, R.B., and Christianson, D.W., in 1996 in a paper entitled "Structure-based design of a sulfonamide probe for fluorescence anisotropy detection of zinc with a carbonic anhydrase-based biosensor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) plasma membranesearch myelin sheathsearch cytosolsearch apical part of cellsearch cytoplasmsearch membranesearch microvillussearch extracellular spacesearch basolateral plasma membranesearch axonsearch extracellular vesicular exosomesearch odontogenesis of dentin-containing toothsearch response to organic substancesearch bicarbonate transportsearch kidney developmentsearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch positive regulation of cellular pH reductionsearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch response to zinc ionsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch response to pHsearch regulation of intracellular pHsearch secretionsearch response to estrogensearch one-carbon metabolic processsearch protein bindingsearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch