1okm Summary

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CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE

The structure was published by Elbaum, D., Nair, S.K., Patchan, M.W., Thompson, R.B., and Christianson, D.W., in 1996 in a paper entitled "Structure-based design of a sulfonamide probe for fluorescence anisotropy detection of zinc with a carbonic anhydrase-based biosensor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch protein bindingsearch metal ion bindingsearch one-carbon metabolic processsearch response to estrogensearch regulation of anion transportsearch bicarbonate transportsearch morphogenesis of an epitheliumsearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch kidney developmentsearch positive regulation of dipeptide transmembrane transportsearch cellular response to fluid shear stresssearch response to organic substancesearch angiotensin-activated signaling pathwaysearch secretionsearch regulation of intracellular pHsearch response to pHsearch small molecule metabolic processsearch response to zinc ionsearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch positive regulation of bone resorptionsearch plasma membranesearch myelin sheathsearch cytosolsearch cytoplasmsearch apical part of cellsearch axonsearch membranesearch extracellular vesicular exosomesearch microvillussearch extracellular spacesearch basolateral plasma membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch