1oj4 Summary



The structure was published by Miallau, L., Alphey, M.S., Kemp, L.E., et al., Eisenreich, W., Rohdich, F., and Hunter, W.N., in 2003 in a paper entitled "Biosynthesis of Isoprenoids: Crystal Structure of 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.01 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE Q8FI04 (1-283) (ISPE_ECOL6)search Escherichia coli CFT073search 100% 283 100%
B 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE Q8FI04 (1-283) (ISPE_ECOL6)search Escherichia coli CFT073search 100% 283 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q8FI04) GHMP Kinase, N-terminal domainsearch, 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase IspEsearch Ribosomal Protein S5; domain 2search, Alpha-Beta Plaitssearch PF00288: GHMP kinases N terminal domainsearch, PF08544: GHMP kinases C terminalsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q8FI04) 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activitysearch ATP bindingsearch transferase activitysearch nucleotide bindingsearch kinase activitysearch terpenoid biosynthetic processsearch isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathwaysearch phosphorylationsearch isoprenoid biosynthetic processsearch

Chain InterPro annotation
A, B 4-diphosphocytidyl-2C-methyl-D-erythritol kinasesearch GHMP kinase N-terminal domainsearch GHMP kinase, C-terminal domainsearch Ribosomal protein S5 domain 2-type fold, subgroupsearch Ribosomal protein S5 domain 2-type foldsearch