1oit Summary



The structure was published by Anderson, M., Beattie, J.F., Breault, G.A., et al., Stanway, J., Thomas, A.P., and Jewsbury, P.J., in 2003 in a paper entitled "Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein bindingsearch nucleotide bindingsearch protein kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch ATP bindingsearch cyclin bindingsearch transferase activitysearch kinase activitysearch metal ion bindingsearch histone kinase activitysearch phosphorylationsearch positive regulation of transcription, DNA-templatedsearch G1/S transition of mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch protein phosphorylationsearch mitotic nuclear divisionsearch cellular response to nitric oxidesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch regulation of gene silencingsearch DNA replicationsearch DNA repairsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch potassium ion transportsearch cell cyclesearch histone phosphorylationsearch mitotic G1 DNA damage checkpointsearch cellular response to DNA damage stimulussearch Ras protein signal transductionsearch positive regulation of cell proliferationsearch centrosome duplicationsearch blood coagulationsearch cell divisionsearch meiotic nuclear divisionsearch mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch cytoplasmsearch endosomesearch nucleoplasmsearch cytosolsearch cytoskeletonsearch transcription factor complexsearch cyclin-dependent protein kinase holoenzyme complexsearch Cajal bodysearch chromosome, telomeric regionsearch nucleussearch condensed chromosomesearch centrosomesearch Y chromosomesearch X chromosomesearch microtubule organizing centersearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch