1oi9 Summary

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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 6-CYCLOHEXYLMETHYLOXY-2-ANILINO-PURINE INHIBITOR

The structure was published by Hardcastle, I.R., Arris, C.E., Bentley, J., et al., Pratt, D.J., Wang, L.-Z., and Whitfield, H.J., in 2004 in a paper entitled "N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 302 98%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 302 98%
B CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%
D CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P24941) protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch histone kinase activitysearch metal ion bindingsearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activitysearch cyclin bindingsearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch cytosolsearch nucleoplasmsearch endosomesearch condensed chromosomesearch X chromosomesearch nucleussearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch cytoskeletonsearch Y chromosomesearch transcription factor complexsearch Cajal bodysearch cytoplasmsearch centrosomesearch G1/S transition of mitotic cell cyclesearch meiotic cell cyclesearch mitotic cell cyclesearch phosphorylationsearch DNA replicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to nitric oxidesearch cell cyclesearch protein phosphorylationsearch regulation of gene silencingsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch meiotic nuclear divisionsearch blood coagulationsearch Ras protein signal transductionsearch mitotic nuclear divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch cell divisionsearch mitotic G1 DNA damage checkpointsearch centrosome duplicationsearch cellular response to DNA damage stimulussearch DNA repairsearch histone phosphorylationsearch potassium ion transportsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of cell proliferationsearch positive regulation of transcription, DNA-templatedsearch
B, D (P20248) protein kinase bindingsearch nucleussearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch