1ohh Summary

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BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE INHIBITOR PROTEIN IF1

The structure was published by Cabezon, E., Montgomery, M.G., Leslie, A.G.W., and Walker, J.E., in 2003 in a paper entitled "The Structure of Bovine F1-ATPase in Complex with its Regulatory Protein If1" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This entry contains 18 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, MITOCHONDRIAL P19483 (44-553) (ATPA_BOVIN)search Bos taurussearch 92% 510 95%
B ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, MITOCHONDRIAL P19483 (44-553) (ATPA_BOVIN)search Bos taurussearch 92% 510 95%
C ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, MITOCHONDRIAL P19483 (44-553) (ATPA_BOVIN)search Bos taurussearch 92% 510 95%
D ATP SYNTHASE BETA CHAIN, MITOCHONDRIAL P00829 (47-528) (ATPB_BOVIN)search Bos taurussearch 91% 482 97%
E ATP SYNTHASE BETA CHAIN, MITOCHONDRIAL P00829 (47-528) (ATPB_BOVIN)search Bos taurussearch 91% 482 97%
F ATP SYNTHASE BETA CHAIN, MITOCHONDRIAL P00829 (47-528) (ATPB_BOVIN)search Bos taurussearch 91% 482 97%
G ATP SYNTHASE GAMMA CHAIN, MITOCHONDRIAL P05631 (26-297) (ATPG_BOVIN)search Bos taurussearch 91% 272 36%
H ATPASE INHIBITOR, MITOCHONDRIAL P01096 (26-109) (ATIF1_BOVIN)search Bos taurussearch < 90% 84 52%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P19483 (44 - 553) ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, MITOCHONDRIAL Bos taurus
P00829 (47 - 528) ATP SYNTHASE BETA CHAIN, MITOCHONDRIAL Bos taurus
P05631 (26 - 297) ATP SYNTHASE GAMMA CHAIN, MITOCHONDRIAL Bos taurus
P01096 (26 - 109) ATPASE INHIBITOR, MITOCHONDRIAL Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C (P19483) C-terminal domain of alpha and beta subunits of F1 ATP synthasesearch, N-terminal domain of alpha and beta subunits of F1 ATP synthasesearch, RecA protein-like (ATPase-domain)search Elongation Factor Tu (Ef-tu); domain 3search, P-loop containing nucleotide triphosphate hydrolasessearch, Lysinsearch PF00006: ATP synthase alpha/beta family, nucleotide-binding domainsearch, PF00306: ATP synthase alpha/beta chain, C terminal domainsearch, PF02874: ATP synthase alpha/beta family, beta-barrel domainsearch
D, E, F (P00829) C-terminal domain of alpha and beta subunits of F1 ATP synthasesearch, N-terminal domain of alpha and beta subunits of F1 ATP synthasesearch, RecA protein-like (ATPase-domain)search Thrombin, subunit Hsearch, P-loop containing nucleotide triphosphate hydrolasessearch, Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3search PF00006: ATP synthase alpha/beta family, nucleotide-binding domainsearch, PF00306: ATP synthase alpha/beta chain, C terminal domainsearch, PF02874: ATP synthase alpha/beta family, beta-barrel domainsearch
G (P05631) ATP synthase (F1-ATPase), gamma subunitsearch Helix Hairpinssearch PF00231: ATP synthasesearch
H F1 ATPase inhibitor, IF1, C-terminal domainsearch Single helix binsearch Mitochondrial ATPase inhibitor, IATPsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C (P19483) ATP metabolic processsearch proton transportsearch transportsearch ATP biosynthetic processsearch ion transportsearch ATP synthesis coupled proton transportsearch ATP hydrolysis coupled proton transportsearch ATP bindingsearch proton-transporting ATPase activity, rotational mechanismsearch protein bindingsearch nucleotide bindingsearch proton-transporting ATP synthase activity, rotational mechanismsearch hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancessearch plasma membranesearch mitochondrial inner membranesearch membranesearch proton-transporting two-sector ATPase complex, catalytic domainsearch mitochondrionsearch mitochondrial proton-transporting ATP synthase complexsearch proton-transporting ATP synthase complex, catalytic core F(1)search
D, E, F (P00829) proton transportsearch negative regulation of cell adhesion involved in substrate-bound cell migrationsearch ATP catabolic processsearch angiogenesissearch ATP metabolic processsearch ATP synthesis coupled proton transportsearch ion transportsearch ATP biosynthetic processsearch regulation of intracellular pHsearch osteoblast differentiationsearch lipid metabolic processsearch transportsearch ATP hydrolysis coupled proton transportsearch hydrolase activitysearch ATP bindingsearch protein bindingsearch MHC class I protein bindingsearch ATPase activitysearch nucleotide bindingsearch proton-transporting ATPase activity, rotational mechanismsearch proton-transporting ATP synthase activity, rotational mechanismsearch hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancessearch mitochondrionsearch mitochondrial membranesearch cell surfacesearch mitochondrial nucleoidsearch membranesearch proton-transporting ATP synthase complex, catalytic core F(1)search mitochondrial inner membranesearch mitochondrial proton-transporting ATP synthase complexsearch extracellular vesicular exosomesearch plasma membranesearch nucleussearch proton-transporting two-sector ATPase complex, catalytic domainsearch
G (P05631) proton transportsearch ATP catabolic processsearch transportsearch ATP biosynthetic processsearch ion transportsearch ATP synthesis coupled proton transportsearch protein bindingsearch ATPase activitysearch poly(A) RNA bindingsearch proton-transporting ATPase activity, rotational mechanismsearch proton-transporting ATP synthase activity, rotational mechanismsearch proton-transporting ATP synthase complex, catalytic core F(1)search mitochondrial inner membranesearch mitochondrionsearch extracellular vesicular exosomesearch mitochondrial proton-transporting ATP synthase complexsearch membranesearch
H (P01096) negative regulation of nucleotide metabolic processsearch enzyme inhibitor activitysearch mitochondrionsearch

Chain InterPro annotation
A, B, C ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainsearch ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminalsearch ATPase, F1 complex alpha/beta subunit, N-terminal domainsearch ATPase, F1 complex, alpha subunitsearch ATPase, alpha/beta subunit, nucleotide-binding domain, active sitesearch ATP synthase subunit alpha-like domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
D, E, F ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainsearch ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminalsearch AAA+ ATPase domainsearch ATPase, F1 complex alpha/beta subunit, N-terminal domainsearch ATPase, F1 complex, beta subunitsearch ATPase, alpha/beta subunit, nucleotide-binding domain, active sitesearch ATPase, F1 complex beta subunit/V1 complex, C-terminalsearch P-loop containing nucleoside triphosphate hydrolasesearch
G ATPase, F1 complex, gamma subunitsearch ATPase, F1 complex, gamma subunit conserved sitesearch ATPase, F1 complex, gamma subunit domainsearch
H ATPase inhibitor, IATP, mitochondriasearch