1ogu Summary

pdbe.org/1ogu
spacer

STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR

The structure was published by Sayle, K.L., Bentley, J., Boyle, F.T., et al., Pratt, D.J., Wang, L.Z., and Griffin, R.J., in 2003 in a paper entitled "Structure-Based Design of 2-Arylamino-4-Cyclohexyl Methyl-5-Nitroso-6-Aminopyrimidine Inhibitors of Cyclin-Dependent Kinases 1 and 2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 302 98%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 302 98%
B CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 98%
D CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) protein kinase activitysearch protein bindingsearch transferase activitysearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch cyclin bindingsearch metal ion bindingsearch histone kinase activitysearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch meiotic cell cyclesearch phosphorylationsearch cellular response to nitric oxidesearch meiotic nuclear divisionsearch potassium ion transportsearch cellular response to DNA damage stimulussearch Ras protein signal transductionsearch G2/M transition of mitotic cell cyclesearch mitotic nuclear divisionsearch DNA replicationsearch cell divisionsearch DNA repairsearch G1/S transition of mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch blood coagulationsearch positive regulation of DNA-dependent DNA replication initiationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitotic G1 DNA damage checkpointsearch positive regulation of transcription, DNA-templatedsearch mitotic cell cyclesearch positive regulation of cell proliferationsearch regulation of gene silencingsearch histone phosphorylationsearch centrosome duplicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell cyclesearch Cajal bodysearch nucleoplasmsearch X chromosomesearch Y chromosomesearch centrosomesearch cyclin-dependent protein kinase holoenzyme complexsearch cytosolsearch endosomesearch cytoplasmsearch microtubule organizing centersearch cytoskeletonsearch condensed chromosomesearch transcription factor complexsearch nucleussearch chromosome, telomeric regionsearch
B, D (P20248) protein kinase bindingsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch regulation of G2/M transition of mitotic cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch