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EBI PDBe PDBeView

PDBe Entry: 1og2 view

STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9
Summary
Header ELECTRON TRANSPORTsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.6 Å, R-factor: 21.0%, Free R-factor: 25.9%, Spacegroup: P 3 2 1
Released 17/07/2003, deposition: 23/04/2003, last revision: 24/02/2009
Authors Williams, P.A.search; Cosme, J.search; Ward, A.search; Angove, H.C.search; Matak Vinkovic, D.search; Jhoti, H.search
Primary citation Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin
NATUREsearch vol:424, pag:464 (2003) [PubMed ID 12861225 ]search
Keywords DRUG METABOLISMsearch, ELECTRON TRANSPORTsearch, OXIDOREDUCTASEsearch, HEMEsearch, MONOOXYGENASEsearch
EC 1.14.13.48 ExPASy BRENDA search 1.14.13.49 ExPASy BRENDA search 1.14.13.80 ExPASy BRENDA search (A B)
Organism Homo sapiens(human) 9606search(A B)
UniProt Cytochrome P450 2C9 (EC 1.14.13.80) ((R)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 6-monooxygenase) (EC 1.14.13.49) ((S)-limonene 7-monooxygenase) (CYPIIC9) (P450 PB-1) (P450 MP-4/MP-8) (S-mephenytoin 4-hydroxylase) (P-450MP) P11712search (A B)
Solvent A, B
Polymers
Id Name Type UniProt Residues Observed
A, B CYTOCHROME P450 2C9 Protein P11712 (CP2C9_HUMAN)search
 475 97%
Heterogens
Id Name Ligands
A, B HEME C HEC search
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