1oey Summary

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HETERODIMER OF P40PHOX AND P67PHOX PB1 DOMAINS FROM HUMAN NADPH OXIDASE

The structure was published by Wilson, M.I., Gill, D.J., Perisic, O., Quinn, M.T., and Williams, R.L., in 2003 in a paper entitled "Pb1 Domain-Mediated Heterodimerization in Nadph Oxidase and Signaling Complexes of Atypical Protein Kinase C with Par6 and P62" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely NEUTROPHIL CYTOSOL FACTOR 2 and NEUTROPHIL CYTOSOL FACTOR 4.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NEUTROPHIL CYTOSOL FACTOR 2 P19878 (352-429) (NCF2_HUMAN)search Homo sapienssearch < 90% 83 98%
B NEUTROPHIL CYTOSOL FACTOR 2 P19878 (352-429) (NCF2_HUMAN)search Homo sapienssearch < 90% 83 98%
C NEUTROPHIL CYTOSOL FACTOR 2 P19878 (352-429) (NCF2_HUMAN)search Homo sapienssearch < 90% 83 98%
D NEUTROPHIL CYTOSOL FACTOR 2 P19878 (352-429) (NCF2_HUMAN)search Homo sapienssearch < 90% 83 98%
J NEUTROPHIL CYTOSOL FACTOR 4 Q15080 (237-339) (NCF4_HUMAN)search Homo sapienssearch 100% 107 98%
K NEUTROPHIL CYTOSOL FACTOR 4 Q15080 (237-339) (NCF4_HUMAN)search Homo sapienssearch 100% 107 98%
L NEUTROPHIL CYTOSOL FACTOR 4 Q15080 (237-339) (NCF4_HUMAN)search Homo sapienssearch 100% 107 98%
M NEUTROPHIL CYTOSOL FACTOR 4 Q15080 (237-339) (NCF4_HUMAN)search Homo sapienssearch 100% 107 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P19878 (352 - 429) NEUTROPHIL CYTOSOL FACTOR 2 Homo sapiens
Q15080 (237 - 339) NEUTROPHIL CYTOSOL FACTOR 4 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D PB1 domainsearch Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1search PB1 domainsearch
J, K, L, M (Q15080) PB1 domainsearch Ubiquitin-like (UB roll)search PF00564: PB1 domainsearch
Chain InterPro annotation
A, B, C, D Phox/Bem1psearch
J, K, L, M Phox/Bem1psearch Neutrophil cytosol factor P40search