1o6y Summary

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CATALYTIC DOMAIN OF PKNB KINASE FROM MYCOBACTERIUM TUBERCULOSIS

The structure was published by Ortiz-Lombardia, M., Pompeo, F., Boitel, B., and Alzari, P.M., in 2003 in a paper entitled "Crystal Structure of the Catalytic Domain of the Pknb Serine/Threonine Kinase from Mycobacterium Tuberculosis" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE PKNB. This molecule has the UniProt identifier P9WI81 (PKNB_MYCTU)search. The sample contained 299 residues which is < 90% of the natural sequence. Out of 299 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE PKNB P9WI81 (1-279) (PKNB_MYCTU)search Mycobacterium tuberculosis H37Rvsearch < 90% 299 86%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WI81 (1 - 279) SERINE/THREONINE-PROTEIN KINASE PKNB Mycobacterium tuberculosis H37Rv

Chain Structural classification (SCOP) Structural classification (CATH)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search

Chain ID Molecular function (GO) Biological process (GO)
A (P9WI81) protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch