1o6k Summary

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STRUCTURE OF ACTIVATED FORM OF PKB KINASE DOMAIN S474D WITH GSK3 PEPTIDE AND AMP-PNP

The structure was published by Yang, J., Cron, P., Good, V.M., Thompson, V., Hemmings, B.A., and Barford, D., in 2002 in a paper entitled "Crystal Structure of an Activated Akt/Protein Kinase B Ternary Complex with Gsk-3 Peptide and AMP-Pnp" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely RAC-BETA SERINE/THREONINE PROTEIN KINASE and GLYCOGEN SYNTHASE KINASE-3 BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RAC-BETA SERINE/THREONINE PROTEIN KINASE P31751 (146-481) (AKT2_HUMAN)search Homo sapienssearch < 90% 336 94%
C GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (3-12) (GSK3B_HUMAN)search Homo sapienssearch 91% 10 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P31751 (146 - 481) RAC-BETA SERINE/THREONINE PROTEIN KINASE Homo sapiens
P49841 (3 - 12) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch
C (P49841)

Chain ID Biological process (GO) Molecular function (GO)
A (P31751) protein phosphorylationsearch protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch
C