› 1o5w

X-ray diffraction
3.2Å resolution

The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase A

Released:
DOI: 10.2210/pdb1o5w/pdb
PDB entry 1o5w coloured by chain, front view.
PDB entry 1o5w coloured by chain, side view.
PDB entry 1o5w coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors.
Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T
J Mol Biol 338 103-14 (2004)
PMID: 15050826

Function and Biology Details

Reactions catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amine oxidase [flavin-containing] A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 534 amino acids
Theoretical weight: 60.61 KDa
Source organism: Rattus norvegicus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P21396 (Residues: 1-526; Coverage: 100%)
Gene name: Maoa
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 4 x FAD
1 bound ligand:
Ligand MLG 4 x MLG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 157.56Å b: 157.56Å c: 257.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.22 0.282
Expression system: Saccharomyces cerevisiae

Quick links

Citations

21 review citations

The therapeutic potential of monoamine oxidase inhibitors.
Youdim et al. (2006)
20 more

14 mentions without citation

Predicting monoamine oxidase inhibitory activity through ligand-based models.
Vilar et al. (2012)
13 more