1o4p Summary

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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791.

The structure was published by Lange, G., Lesuisse, D., Deprez, P., et al., Broto, P., Sarubbi, E., and Mandine, E., in 2003 in a paper entitled "Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC. This molecule has the UniProt identifier P12931 (SRC_HUMAN)search. The sample contained 108 residues which is < 90% of the natural sequence. Out of 108 residues 105 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC P12931 (145-252) (SRC_HUMAN)search Homo sapienssearch 100% 108 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (145 - 252) PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P12931) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch
Chain InterPro annotation
A SH2 domainsearch