1o1o Summary

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Deoxy hemoglobin (A,C:V1M,V62L; B,D:V1M,V67L)

The structure has not been published. The depositing authors are Brucker, E.A.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin Alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin Alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch membranesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch bicarbonate transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch oxygen transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch
B, D (P68871) iron ion bindingsearch metal ion bindingsearch protein bindingsearch heme bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch extracellular vesicular exosomesearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch bicarbonate transportsearch blood coagulationsearch renal absorptionsearch regulation of blood vessel sizesearch regulation of blood pressuresearch oxygen transportsearch platelet aggregationsearch oxidation-reduction processsearch small molecule metabolic processsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch transportsearch nitric oxide transportsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch