1o1o Summary

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Deoxy hemoglobin (A,C:V1M,V62L; B,D:V1M,V67L)

The structure has not been published. The depositing authors are Brucker, E.A.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin Alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin Alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch membranesearch extracellular regionsearch cytosolic small ribosomal subunitsearch cytosolsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch oxidation-reduction processsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch bicarbonate transportsearch oxygen transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch
B, D (P68871) hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch heme bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch iron ion bindingsearch haptoglobin bindingsearch oxygen transportsearch regulation of blood pressuresearch bicarbonate transportsearch renal absorptionsearch platelet aggregationsearch oxidation-reduction processsearch small molecule metabolic processsearch protein heterooligomerizationsearch transportsearch positive regulation of nitric oxide biosynthetic processsearch blood coagulationsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch response to hydrogen peroxidesearch nitric oxide transportsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch