1o1k Summary

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Deoxy hemoglobin (A,C:V1M; B,D:V1M,V67W)

The structure has not been published. The depositing authors are Brucker, E.A.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin Alpha chain and Hemoglobin Beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 99%
C Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 99%
B Hemoglobin Beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin Beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin Alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin Beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) hydrogen peroxide catabolic processsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch small molecule metabolic processsearch transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch hemoglobin complexsearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch metal ion bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch oxygen transporter activitysearch
B, D (P68871) platelet aggregationsearch oxygen transportsearch bicarbonate transportsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch regulation of blood vessel sizesearch blood coagulationsearch small molecule metabolic processsearch oxidation-reduction processsearch renal absorptionsearch transportsearch protein heterooligomerizationsearch extracellular vesicular exosomesearch blood microparticlesearch extracellular regionsearch cytosolsearch hemoglobin complexsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch iron ion bindingsearch peroxidase activitysearch protein bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch