1o1k Summary

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Deoxy hemoglobin (A,C:V1M; B,D:V1M,V67W)

The structure has not been published. The depositing authors are Brucker, E.A.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin Alpha chain and Hemoglobin Beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 99%
C Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 99%
B Hemoglobin Beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin Beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin Alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin Beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch small molecule metabolic processsearch oxidation-reduction processsearch extracellular regionsearch cytosolsearch extracellular exosomesearch hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch
B, D (P68871) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin bindingsearch metal ion bindingsearch bicarbonate transportsearch oxygen transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch regulation of blood pressuresearch platelet aggregationsearch nitric oxide transportsearch receptor-mediated endocytosissearch small molecule metabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch transportsearch renal absorptionsearch regulation of blood vessel sizesearch hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch