1o1k Summary

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Deoxy hemoglobin (A,C:V1M; B,D:V1M,V67W)

The structure has not been published. The depositing authors are Brucker, E.A.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin Alpha chain and Hemoglobin Beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 99%
C Hemoglobin Alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 99%
B Hemoglobin Beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin Beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin Alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin Beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) transportsearch bicarbonate transportsearch oxygen transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch small molecule metabolic processsearch protein heterooligomerizationsearch positive regulation of cell deathsearch oxidation-reduction processsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch heme bindingsearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch oxygen bindingsearch
B, D (P68871) protein heterooligomerizationsearch oxygen transportsearch bicarbonate transportsearch regulation of blood pressuresearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch regulation of blood vessel sizesearch nitric oxide transportsearch blood coagulationsearch small molecule metabolic processsearch transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch renal absorptionsearch oxidation-reduction processsearch hemoglobin complexsearch extracellular regionsearch cytosolsearch blood microparticlesearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch heme bindingsearch hemoglobin bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch